Okadaic acid, 97% | C44H68O13 | CID 131839562 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological
Okadaic acid is a naturally occuring polyether toxin produced by marine dinoflagellates. It is a potent and selective inhibitor of protein phosphatases, inhibiting PP2A completely at 1nM and PP1 at higher concentrations (IC 50 =10-15nM). PP2B is much less sensitive to okadaic acid than PP1, while PP2C is …
As it turns out, in the brain it hyperphosphorylates tau, which causes it to tangle. Okadaic acid-treatment applied to cultures containing predominantly differentiated chondrocytes (after day 4) did not influence the cartilage formation. 3H-thymidine and bromodeoxyuridine incorporation-assays demonstrated enhanced cell proliferation in the okadaic acid-treated colonies compared to that of the untreated ones. Okadaic acid (OA) is one of the most frequent and worldwide distributed marine toxins. It is easily accumulated by shellfish, mainly bivalve mollusks and fish, and, subsequently, can be consumed by humans causing alimentary intoxications. OA is the main representative diarrheic shellfish poisoning (DSP) toxin and its ingestion induces gastrointestinal symptoms, although it is not considered Okadaic acid is a naturally occuring polyether toxin produced by marine dinoflagellates.
”Crystal structure of the tumorpromoter okadaic acid bound to protein phosphatase-1”. Journal of Biological Chemistry. DOI: 10.1074. However toxins produced by phytoplankton are accumulated by mussels and oysters and may result in poisoning when consumed. Okadaic acid is the toxin that Microcystin-LR and okadaic acid-induced cellular effects: a dualistic response. FEBS Lett.
av S Granström — Passive immunization targeting the N- terminal region of phosphorylated tau (residues 68-71) improves spatial memory in okadaic acid induced
Pris: 639 kr. häftad, 2014.
Microcystin-LR and okadaic acid-induced cellular effects: a dualistic response. FEBS Lett. 2004 Jan;557(1-3):1-8. Ibelings BW, Chorus I. Accumulation of
Okadaic-acid, a 38-carbon fatty acid isolated from the black sponge Halichondria okadai , can stimulate lipolysis by promoting the phosphorylation of several proteins in adipocytes.
PubMedID: 23591640. Inhibitory effect of a marine-sponge toxin, okadaic acid
Okadaic acid is a polyether derivative of 38-carbon fatty acid, and is implicated as the causative agent of diarrhetic shellfish poisoning. It is a potent tumour promoter that is not an activator of protein kinase C, but is a powerful inhibitor of protein phosphatases-1 and -2A (PP1 and PP2A) in vitro.
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As it turns out, in the brain it hyperphosphorylates tau, which causes it to tangle. Okadaic Acid (sodium salt) solution in methanol reference standards available online at LGC Standards, for food and beverage analysis. Okadaic acid is a potent inhibitor of protein phosphatase 1/2A with IC50 values of 19 nM and 0.2 nM for protein phosphatase 1 and protein phosphatase 2A, respectively [1]. Protein phosphatase 1 (PP1) and protein phosphatase 2A (PP2A) are two major mammalian serine/threonine protein phosphatases and are activated in response to Ca2+ cascades as well as increased protein kinase A activity [2]. Okadaic acid is a toxic polyether compound of a C 38 fatty acid (Fig.
Non-TPA type promoting agent of carcinogenesis. Okadaic acid is extracted from black sponges of the genus Halichondria.
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Quercetin Protects against Okadaic Acid-Induced Injury via MAPK and PI3K/Akt/ GSK3β Signaling Pathways in HT22 Hippocampal Neurons. Fig 2. Effects of OA on
It is produced by DINOFLAGELLATES and causes diarrhetic SHELLFISH POISONING.